Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Coaxial nanofibers outperform uniaxial nanofibers for the loading and release of pyrroloquinoline quinone (PQQ) for biomedical applications

Author affiliations

Abstract

Pyrroloquinoline quinone (PQQ), present in breast milk and various foods, is highly recommended as an antioxidant, anti-inflammatory agent, and a cofactor in redox reactions in several biomedical fields. Moreover, PQQ has neuroprotective effects on nervous system disorders and immunosuppressive effects on different diseases. Herein, we report on the optimum fabrication of electrospun CS/PVA coaxial, core/shell, and uniaxial nanofibers. The morphological, elemental, and chemical structure of the fabricated nanofibers were investigated and discussed. PQQ, as a drug, was loaded on the uniaxial nanofibers and in the core of the coaxial nanofibers and the sustained and controlled release of PQQ was compared and discussed. The results revealed the privilege of the coaxial over the uniaxial nanofibers in the sustained release and reduction of the initial burst of PQQ. Remarkably, the results revealed a higher degree of swelling for CS/PVA hollow nanofibers compared to that of the uniaxial and the coaxial nanofibers. The coaxial nanofibers showed a lower release rate than the uniaxial nanofibers. Moreover, the CS/PVA coaxial nanofibers loaded with PQQ were found to enhance cell viability and proliferation. Therefore, the CS/PVA coaxial nanofibers loaded with PQQ assembly is considered a superior drug delivery system for PQQ release.

Graphical abstract: Coaxial nanofibers outperform uniaxial nanofibers for the loading and release of pyrroloquinoline quinone (PQQ) for biomedical applications

Back to tab navigation

Article information


Submitted
20 Apr 2020
Accepted
06 Jun 2020
First published
08 Jun 2020

This article is Open Access

Nanoscale Adv., 2020, Advance Article
Article type
Paper

Coaxial nanofibers outperform uniaxial nanofibers for the loading and release of pyrroloquinoline quinone (PQQ) for biomedical applications

S. Ibrahim, M. Y. Rezk, M. Ismail, T. Abdelrahman, M. Sharkawy, A. Abdellatif and N. K. Allam, Nanoscale Adv., 2020, Advance Article , DOI: 10.1039/D0NA00311E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements