Issue 8, 2020

Biologically interfaced nanoplasmonic sensors


Understanding biointerfacial processes is crucial in various fields across fundamental and applied biology, but performing quantitative studies via conventional characterization techniques remains challenging due to instrumentation as well as analytical complexities and limitations. In order to accelerate translational research and address current challenges in healthcare and medicine, there is an outstanding need to develop surface-sensitive technologies with advanced measurement capabilities. Along this line, nanoplasmonic sensing has emerged as a powerful tool to quantitatively study biointerfacial processes owing to its high spatial resolution at the nanoscale. Consequently, the development of robust biological interfacing strategies becomes imperative to maximize its characterization potential. This review will highlight and discuss the critical role of biological interfacing within the context of constructing nanoplasmonic sensing platforms for biointerfacial science applications. Apart from paving the way for the development of highly surface-sensitive characterization tools that will spur fundamental biological interaction studies and improve the overall understanding of biological processes, the basic principles behind biointerfacing strategies presented in this review are also applicable to other fields that involve an interface between an inorganic material and a biological system.

Graphical abstract: Biologically interfaced nanoplasmonic sensors

Article information

Article type
08 Apr 2020
26 Jun 2020
First published
02 Jul 2020
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2020,2, 3103-3114

Biologically interfaced nanoplasmonic sensors

A. R. Ferhan, B. K. Yoon, W. Jeon and N. Cho, Nanoscale Adv., 2020, 2, 3103 DOI: 10.1039/D0NA00279H

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