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Issue 6, 2020
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Connectability of protein cages

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Abstract

Regular, hollow proteinaceous nanoparticles are widespread in nature. The well-defined structures as well as diverse functions of naturally existing protein cages have inspired the development of new nanoarchitectures with desired capabilities. In such approaches, a key functionality is “connectability”. Engineering of interfaces between cage building blocks to modulate intra-cage connectability leads to protein cages with new morphologies and assembly–disassembly properties. Modification of protein cage surfaces to control inter-cage connectability enables their arrangement into lattice-like nanomaterials. Here, we review the current progress in control of intra- and inter-cage connectability for protein cage-based nanotechnology development.

Graphical abstract: Connectability of protein cages

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Article information


Submitted
20 Mar 2020
Accepted
27 Apr 2020
First published
18 May 2020

This article is Open Access

Nanoscale Adv., 2020,2, 2255-2264
Article type
Review Article

Connectability of protein cages

K. Majsterkiewicz, Y. Azuma and J. G. Heddle, Nanoscale Adv., 2020, 2, 2255 DOI: 10.1039/D0NA00227E

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