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Small molecule-decorated gold nanoparticles for preparing antibiofilm fabrics

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Abstract

The increase in antibiotic resistance reported worldwide poses an immediate threat to human health and highlights the need to find novel approaches to inhibit bacterial growth. In this study, we present a series of gold nanoparticles (Au NPs) capped by different N-heterocyclic molecules (N_Au NPs) which can serve as broad-spectrum antibacterial agents. Neither the Au NPs nor N-heterocyclic molecules were toxic to mammalian cells. These N_Au NPs can attach to the surface of bacteria and destroy the bacterial cell wall to induce cell death. Sonochemistry was used to coat Au NPs on the surface of fabrics, which showed superb antimicrobial activity against multi-drug resistant (MDR) bacteria as well as excellent efficacy in inhibiting bacterial biofilms produced by MDR bacteria. Our study provides a novel strategy for preventing the formation of MDR bacterial biofilms in a straightforward, low-cost, and efficient way, which holds promise for broad clinical applications.

Graphical abstract: Small molecule-decorated gold nanoparticles for preparing antibiofilm fabrics

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Article information


Submitted
03 Mar 2020
Accepted
27 Apr 2020
First published
28 Apr 2020

This article is Open Access

Nanoscale Adv., 2020, Advance Article
Article type
Communication

Small molecule-decorated gold nanoparticles for preparing antibiofilm fabrics

L. Wang, M. Natan, W. Zheng, W. Zheng, S. Liu, G. Jacobi, I. Perelshtein, A. Gedanken, E. Banin and X. Jiang, Nanoscale Adv., 2020, Advance Article , DOI: 10.1039/D0NA00179A

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