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Au nano-urchins enabled localized surface plasmon resonance sensing of beta amyloid fibrillation

Abstract

Early stage detection of neurodegenerative diseases such as Alzheimer’s disease (AD) is of utmost importance, as it has become one of the leading causes of death of millions of people. The gradual intellectual decline in AD patients is an outcome of fibrillation of amyloid beta 1-42 (Aβ1-42) peptides in brain. In this paper, we present localized surface plasmon resonance (LSPR) based sensing of Aβ1-42 fibrillation using Au nano-urchins. Strongly localized field confinement at the spiky nanostructures of nano-urchin surfaces enables them to detect very low concentrations of Aβ1-42. In addition, the LSPR peak of Au nano-urchins, which is very sensitive to ambient conditions, shows significant responses at different fibrillation stages of Aβ1-42. Reduction in LSPR peak intensity with increase in the fibrillation is chosen as the sensing parameter here. This paper in this context provides LSPR based highly sensitive, label-free and real-time sensing of Aβ1-42 fibrillation that is highly advantageous compared to the existing techniques which require binding additives or fluorescent biomarkers.

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Article information


Accepted
14 Mar 2020
First published
17 Mar 2020

This article is Open Access

Nanoscale Adv., 2020, Accepted Manuscript
Article type
Communication

Au nano-urchins enabled localized surface plasmon resonance sensing of beta amyloid fibrillation

R. V. Nair, J. Pae, P. Padmanabhan, B. Z. Gulyás and M. Vadakke Matham, Nanoscale Adv., 2020, Accepted Manuscript , DOI: 10.1039/D0NA00164C

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