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Nanomaterials for Regulation of Tumor Microenvironment and Theranostics

Abstract

Cancer has become one of the primary threatens of human beings and traditional therapies (including surgery, chemotherapy and radiotherapy) show the restricted therapeutic effect as the complexity of tumor biology. How to utilize the differences between tumor microenvironment (TME) and healthy tissues as well as explore new nanoplatforms that can realize early diagnosis, effective and non-toxic therapy are challenges in cancer theranostics. Numerous researchers have designed multifunctional nanomaterials and investigated their personalized therapy and regulation abilities toward the TME including the oxygen generation, glutathione consumption as well as the production of reactive oxygen species and multi-model imaging effects. This review will introduce the latest progress in the design of multi-functional nanomedicines for the regulation of TME and their theranostics, and it will provide a critical angle for the future development of nanomedicine.

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Article information


Submitted
31 Dec 2019
Accepted
08 Feb 2020
First published
10 Feb 2020

This article is Open Access

Nanoscale Adv., 2020, Accepted Manuscript
Article type
Minireview

Nanomaterials for Regulation of Tumor Microenvironment and Theranostics

W. Zhen, W. Hu, L. Dong, S. An and X. Jiang, Nanoscale Adv., 2020, Accepted Manuscript , DOI: 10.1039/C9NA00816K

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