Jump to main content
Jump to site search

Issue 2, 2020
Previous Article Next Article

Covalently functionalized uniform amino-silica nanoparticles. Synthesis and validation of amine group accessibility and stability

Author affiliations

Abstract

This paper describes the synthesis and characterization of colloidally stable, 18 nm silica nanoparticles that are functionalized with amine groups. Electron microscopy, small-angle X-ray scattering (SAXS), and dynamic light scattering show the amine grafting does not impact particle size. SAXS and DLS confirm the particles do not aggregate at 10 mg mL−1 and pH 2 for 30 days. Ninhydrin analysis, fluorescamine binding, and NMR studies of carboxylic acid binding show that the amines are present on the surface and accessible with maximum loading calculated to be 0.14 mmol g−1. These materials should find a range of use in nanotechnology applications.

Graphical abstract: Covalently functionalized uniform amino-silica nanoparticles. Synthesis and validation of amine group accessibility and stability

Back to tab navigation

Supplementary files

Article information


Submitted
09 Dec 2019
Accepted
15 Jan 2020
First published
16 Jan 2020

This article is Open Access

Nanoscale Adv., 2020,2, 860-868
Article type
Paper

Covalently functionalized uniform amino-silica nanoparticles. Synthesis and validation of amine group accessibility and stability

P. J. Miller and D. F. Shantz, Nanoscale Adv., 2020, 2, 860
DOI: 10.1039/C9NA00772E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements