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Eight biomarkers on a novel strip for early diagnosis of acute myocardial infarction

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Abstract

Accurate detection of markers in human serum is important in the early diagnosis of acute myocardial infarction (AMI). This work presents a novel eight biomarker strip, which combines dry chemistry with a fluorescence lateral flow assay. Eight AMI markers were employed simultaneously for sensitive detection, including cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C), uric acid (UA), myoglobin (Myo), creatine kinase-MB (CK-MB), and cardiac troponin I (cTnI). The strip offers the advantages of simple fabrication, convenience, time-saving detection and accurate assessment for AMI. Moreover, the strip possesses acceptable applicability for human serum. This proposed strategy establishes a remarkable platform for the construction of a multi-target detection strip that is feasible for accurate detection for real human serum samples.

Graphical abstract: Eight biomarkers on a novel strip for early diagnosis of acute myocardial infarction

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Supplementary files

Article information


Submitted
12 Oct 2019
Accepted
09 Dec 2019
First published
17 Dec 2019

This article is Open Access

Nanoscale Adv., 2020, Advance Article
Article type
Paper

Eight biomarkers on a novel strip for early diagnosis of acute myocardial infarction

L. Huang, Y. Zhang, E. Su, Y. Liu, Y. Deng, L. Jin, Z. Chen, S. Li, Y. Zhao and N. He, Nanoscale Adv., 2020, Advance Article , DOI: 10.1039/C9NA00644C

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