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Formation of gadolinium–ferritin from clinical magnetic resonance contrast agents

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Abstract

Gadolinium deposition in the brain following administration of gadolinium-based contrast agents (GBCAs) has led to health concerns. We show that some clinical GBCAs form Gd3+–ferritin nanoparticles at (sub)nanomolar concentrations of Gd3+ under physiological conditions. We describe their structure at atomic resolution and discuss potential relevance for clinical MRI.

Graphical abstract: Formation of gadolinium–ferritin from clinical magnetic resonance contrast agents

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Article information


Submitted
06 Sep 2019
Accepted
29 Aug 2020
First published
31 Aug 2020

This article is Open Access

Nanoscale Adv., 2020, Advance Article
Article type
Communication

Formation of gadolinium–ferritin from clinical magnetic resonance contrast agents

J. Neburkova, A. M. Rulseh, S. L. Y. Chang, H. Raabova, J. Vejpravova, M. Dracinsky, J. Tarabek, J. Kotek, M. Pingle, P. Majer, J. Vymazal and P. Cigler, Nanoscale Adv., 2020, Advance Article , DOI: 10.1039/C9NA00567F

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