Formation of gadolinium–ferritin from clinical magnetic resonance contrast agents†
Gadolinium deposition in the brain following administration of gadolinium-based contrast agents (GBCAs) has led to health concerns. We show that some clinical GBCAs form Gd3+–ferritin nanoparticles at (sub)nanomolar concentrations of Gd3+ under physiological conditions. We describe their structure at atomic resolution and discuss potential relevance for clinical MRI.
- This article is part of the themed collection: Nanoscale Advances HOT Article Collection