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Issue 10, 2020
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Iron homeostasis disorder in piglet intestine

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Abstract

Iron plays an essential role in preventing iron deficiency anemia and ensuring the healthy growth of animals. The special physiological condition of piglets is the main cause of iron deficiency. Iron metabolism in the intestine is the basis for understanding the effects of iron on the health of piglets. In order to scientifically evaluate dietary iron supplementation doses, it is necessary to recognize the effects of iron deficiency and iron overload on piglet intestinal health. Besides, iron as a cofactor is essential for the growth of microorganisms, and microorganisms compete with the host to absorb iron. Under the stress of iron deficiency and iron overload, various control schemes (such as precise nutrition, element balance, elimination of oxidation, etc.) are effective measures to eliminate adverse effects. In this review, we comprehensively review recent findings on the effects of iron deficiency and iron overload on intestinal health. This review will provide a rational design strategy to achieve a reasonable iron supplement, which will guide the use of iron in animal husbandry.

Graphical abstract: Iron homeostasis disorder in piglet intestine

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Article information


Submitted
24 Jun 2020
Accepted
04 Aug 2020
First published
05 Aug 2020

Metallomics, 2020,12, 1494-1507
Article type
Critical Review

Iron homeostasis disorder in piglet intestine

H. Ding, X. Yu and J. Feng, Metallomics, 2020, 12, 1494
DOI: 10.1039/D0MT00149J

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