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Issue 5, 2020
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Peptide bond cleavage in the presence of Ni-containing particles

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Abstract

NiO nanoparticles and non-stoichiometric black NiO were shown to be effective sources of Ni2+ ions causing sequence-selective peptide bond hydrolysis. NiO nanoparticles were as effective in this reaction as their molar equivalent of soluble Ni(II) salt. These findings highlight the efficacy of delivery of toxic Ni2+ by these environmentally available particles.

Graphical abstract: Peptide bond cleavage in the presence of Ni-containing particles

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Article information


Submitted
18 Mar 2020
Accepted
29 Apr 2020
First published
29 Apr 2020

Metallomics, 2020,12, 649-653
Article type
Communication

Peptide bond cleavage in the presence of Ni-containing particles

N. E. Wezynfeld, T. Frączyk, A. Bonna and W. Bal, Metallomics, 2020, 12, 649
DOI: 10.1039/D0MT00070A

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