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Issue 5, 2020
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Studies of the labile lead pool using a rhodamine-based fluorescent probe

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Abstract

Lead is a heavy metal which has long been known to have toxic effects on the body. However, much remains to be learnt about the labile lead pool and cellular uptake of lead. We report here RPb1 that undergoes a 100-fold increase in fluorescence emission in the presence of Pb2+, and which can be applied to study the labile lead pool within cells. We demonstrate the capacity of RPb1 for investigating labile lead pool in DLD-1 cells and changes in labile lead during differentiation of K562 cells.

Graphical abstract: Studies of the labile lead pool using a rhodamine-based fluorescent probe

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Article information


Submitted
03 Mar 2020
Accepted
17 Apr 2020
First published
28 Apr 2020

Metallomics, 2020,12, 644-648
Article type
Communication

Studies of the labile lead pool using a rhodamine-based fluorescent probe

J. Zhu, J. H. Yeo, A. A. Bowyer, N. Proschogo and E. J. New, Metallomics, 2020, 12, 644
DOI: 10.1039/D0MT00056F

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