Jump to main content
Jump to site search


Toxicity of three types of arsenolipids: species-specific effects in Caenorhabditis elegans

Abstract

Although fish and seafood are well known for their nutritional benefits, they contain contaminants that might affect human health. Organic lipid-soluble arsenic species, so called arsenolipids, belong to the emerging contaminants in these food items; their toxicity has yet to be systematically studied. Here, we apply the in vivo model Caenorhabditis elegans to assess the effects of two arsenic-containing hydrocarbons (AsHC), a saturated arsenic-containing fatty acid (AsFA), and an arsenic-containing triacylglyceride (AsTAG) in a whole organism. Although all arsenolipids were highly bioavailable in Caenorhabditis elegans, only the AsHCs were substantially metabolized to thioxylated or shortened metabolic products and induced significant toxicity, affecting both survival and development. Furthermore, the AsHCs were several fold more potent as compared to the toxic reference arsenite. This study clearly indicates the need for a full hazard identification of subclasses of arsenolipids to assess whether they poses a risk to human health.

Back to tab navigation

Supplementary files

Article information


Accepted
12 Mar 2020
First published
23 Mar 2020

Metallomics, 2020, Accepted Manuscript
Article type
Paper

Toxicity of three types of arsenolipids: species-specific effects in Caenorhabditis elegans

J. Bornhorst, F. Ebert, S. Meyer, V. Ziemann, C. Xiong, N. Guttenberg, A. Raab, J. Baesler, M. Aschner, J. Feldmann, K. A. Francesconi, G. Raber and T. Schwerdtle, Metallomics, 2020, Accepted Manuscript , DOI: 10.1039/D0MT00039F

Social activity

Search articles by author

Spotlight

Advertisements