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Surface biofunctionalization to improve the efficacy of biomaterial substrates to be used in regenerative medicine

Abstract

Surface biofunctionalization has emerged in the past decade as a rising tool in Tissue Engineering and Regenerative Medicine (TERM) approaches. The development of biomaterials with regenerative properties is challenging, mainly due to the requirement of obtaining a surface that promotes cell attachment, proliferation and differentiation. Biomolecules, namely extracellular matrix proteins and growth factors, play a key role in the wound healing cascade mediating a wide range of cellular activities. Therefore, the immobilization of such biomolecules at the surface of biomaterials has a remarkable interest for TERM strategies. Numerous variants can be used to biofunctionalize the surface of biomaterials, being classified as non-covalent and covalent immobilization strategies. Importantly, the maintenance of stable/available bioactive factors needs also to be considered. In this review, a wide range of bioactive molecules and different biofunctionalization strategies will be discussed, and the most relevant results achieved in the novel and most promising strategies.

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Article information


Accepted
26 May 2020
First published
26 May 2020

Mater. Horiz., 2020, Accepted Manuscript
Article type
Review Article

Surface biofunctionalization to improve the efficacy of biomaterial substrates to be used in regenerative medicine

M. R. Casanova, R. Reis, A. Martins and N. M. Neves, Mater. Horiz., 2020, Accepted Manuscript , DOI: 10.1039/D0MH00542H

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