Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Surface biofunctionalization to improve the efficacy of biomaterial substrates to be used in regenerative medicine

Author affiliations

Abstract

Surface biofunctionalization has emerged in the past decade as a rising tool in Tissue Engineering and Regenerative Medicine (TERM) approaches. The development of biomaterial substrates with regenerative properties is challenging, mainly due to the requirement of obtaining a surface that promotes cell attachment, proliferation and differentiation. Biomolecules, namely extracellular matrix proteins and growth factors, play a key role in the wound healing cascade, mediating a wide range of cellular activities. Therefore, the immobilization of such biomolecules at the surface of biomaterials has a remarkable interest for TERM strategies. Numerous variants can be used to biofunctionalize the surface of biomaterials, being classified as non-covalent and covalent immobilization strategies. Importantly, the maintenance of stable/available bioactive factors needs also to be considered. In this review, a wide range of bioactive molecules and different biofunctionalization strategies will be discussed, as well as the most relevant results achieved in the novel and most promising strategies.

Graphical abstract: Surface biofunctionalization to improve the efficacy of biomaterial substrates to be used in regenerative medicine

Back to tab navigation

Article information


Submitted
31 Mar 2020
Accepted
26 May 2020
First published
26 May 2020

Mater. Horiz., 2020, Advance Article
Article type
Review Article

Surface biofunctionalization to improve the efficacy of biomaterial substrates to be used in regenerative medicine

M. R. Casanova, R. L. Reis, A. Martins and N. M. Neves, Mater. Horiz., 2020, Advance Article , DOI: 10.1039/D0MH00542H

Social activity

Search articles by author

Spotlight

Advertisements