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Rational design of semiconducting polymer brushes as cancer theranostics

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Abstract

Photonic theranostics (PTs) generally contain optical agents for the optical sensing of biomolecules and therapeutic components for converting light into heat or chemical energy. Semiconducting polymer nanoparticles (SPNs) as advanced PTs possessing good biocompatibility, stable photophysical properties, and sensitive and tunable optical responses from the ultraviolet to near-infrared (NIR) II window (300–1700 nm) have recently aroused great interest. Although semiconducting polymers (SPs) with various building blocks have been synthesized and developed to meet the demands of biophotonic applications, most of the SPNs were made by a nanoprecipitation method that used amphiphilic surfactants to encapsulate SPs. Such binary SP micelles usually exhibit weakened photophysical properties of SPs and undergo dissociation in vivo. SP brushes (SPBs) are products of functional post-modification of SP backbones, which endows unique features to SPNs (e.g. enhanced optical properties and multiple chemical reaction sites for the conjunction of organic/inorganic imaging agents and therapeutics). Furthermore, the SPB-based SPNs can be highly stable due to supramolecular self-assembly and/or chemical crosslinking. In this review, we highlight the recent progress in the development of SPBs for advanced theranostics.

Graphical abstract: Rational design of semiconducting polymer brushes as cancer theranostics

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Article information


Submitted
03 Jan 2020
Accepted
14 Feb 2020
First published
14 Feb 2020

Mater. Horiz., 2020, Advance Article
Article type
Review Article

Rational design of semiconducting polymer brushes as cancer theranostics

Z. Yang, L. Li, A. J. Jin, W. Huang and X. Chen, Mater. Horiz., 2020, Advance Article , DOI: 10.1039/D0MH00012D

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