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One-step in vivo metabolic labeling as a theranostic approach for overcoming drug-resistant bacterial infections

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Abstract

A bacterial metabolic probe combining D-alanine and a photosensitizer with aggregation-induced emission (AIE) has been developed for in vivo light-up imaging of bacterial walls and efficient antibacterial therapy. This activatable probe could serve as a promising non-antibiotic tool for diagnosis and treatment of biofilms and intracellular bacteria, as well as multi-resistant bacterial infections.

Graphical abstract: One-step in vivo metabolic labeling as a theranostic approach for overcoming drug-resistant bacterial infections

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Article information


Submitted
22 Oct 2019
Accepted
03 Jan 2020
First published
08 Jan 2020

Mater. Horiz., 2020, Advance Article
Article type
Communication

One-step in vivo metabolic labeling as a theranostic approach for overcoming drug-resistant bacterial infections

D. Mao, F. Hu, Kenry, G. Qi, S. Ji, W. Wu, D. Kong and B. Liu, Mater. Horiz., 2020, Advance Article , DOI: 10.1039/C9MH01675A

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