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Twenty-five years of polymersomes: lost in translation?

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Abstract

Soon after the discovery of polymeric vesicles (polymersomes), reports of their high membrane stability raised hopes for the development of next generation vesicles for drug delivery and diagnostic applications. Twenty-five years later, however, liposomes remain the only clinically tested colloidal vesicular formulations. To highlight the translational challenges faced by polymersomes, we critically reviewed a selection of polymersome formulations with a focus on their pharmacokinetic and pharmacodynamic aspects.

Graphical abstract: Twenty-five years of polymersomes: lost in translation?

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Article information


Submitted
19 Oct 2019
Accepted
24 Jan 2020
First published
24 Jan 2020

This article is Open Access

Mater. Horiz., 2020, Advance Article
Article type
Minireview

Twenty-five years of polymersomes: lost in translation?

S. Matoori and J. Leroux, Mater. Horiz., 2020, Advance Article , DOI: 10.1039/C9MH01669D

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