Jump to main content
Jump to site search

Issue 8, 2020
Previous Article Next Article

Hybrid nanoparticle based fluorescence switch for recognition of ketoprofen in aqueous media

Author affiliations

Abstract

A rapid fluorescence method has been developed which describes the sensitive and selective determination of ketoprofen by developing hybrid assemblies composed of silver nanoparticles and organic nanoparticles. Three different ligands were synthesized using various thiourea derivatives and these were processed with organic nanoparticles using a single step re-precipitation method. Hybrid nanoassemblies were developed and consisted of silver nanoparticles and organic nanoparticles, respectively. These were further analysed for their response to various drug molecules and their fluorescence emission spectra were recorded. A non-selective response was observed for hybrid nanoassemblies composed of ethyl isothiocyanate and phenyl isothiocyanate. However, a turn-on fluorescence response to ketoprofen was noticed for the hybrid nanoassembly composed of 1-naphthyl isothiocyanate. Titrations were carried out revealing that with subsequent addition of ketoprofen, a gradual increase in fluorescence emission was noticed. Our sensor can effectively determine ketoprofen up to a detection limit of 34 nM. Moreover, other drug molecules were found to have negligible interference in the sensing of ketoprofen in aqueous media.

Graphical abstract: Hybrid nanoparticle based fluorescence switch for recognition of ketoprofen in aqueous media

Back to tab navigation

Supplementary files

Article information


Submitted
19 May 2020
Accepted
14 Aug 2020
First published
26 Aug 2020

Mol. Syst. Des. Eng., 2020,5, 1428-1436
Article type
Paper

Hybrid nanoparticle based fluorescence switch for recognition of ketoprofen in aqueous media

A. Saini, M. Kaur, Mayank, A. Kuwar, N. Kaur and N. Singh, Mol. Syst. Des. Eng., 2020, 5, 1428
DOI: 10.1039/D0ME00065E

Social activity

Search articles by author

Spotlight

Advertisements