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Nanomaterials for molecular signal amplification in electrochemical nucleic acid biosensing: recent advances and future prospects for point-of-care diagnostics

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Abstract

With the increasing importance of personalized medicine and genomics, biosensors have received considerable attention in various fields, including clinical diagnostics, food inspection and environmental monitoring. In particular, advances in electrochemical biosensing technologies for clinical diagnostics pave the way for ultrasensitive detection of nucleic acid sequences using miniaturized and low-cost devices suitable for point-of-use applications. This account reviews three major amplification strategies utilizing nanomaterials as (i) ‘nanocatalysts’ in electrocatalysis, (ii) redox active reporters (‘nanoreporters’) and (iii) cargos for redox markers (‘nanocarriers’). In addition, and motivated by the need for reproducible and robust sensing, the integration of biosensors with microfluidic tools, including paper-based devices, are also covered.

Graphical abstract: Nanomaterials for molecular signal amplification in electrochemical nucleic acid biosensing: recent advances and future prospects for point-of-care diagnostics

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Publication details

The article was received on 01 Oct 2019, accepted on 08 Nov 2019 and first published on 08 Nov 2019


Article type: Review Article
DOI: 10.1039/C9ME00135B
Mol. Syst. Des. Eng., 2020, Advance Article
  • Open access: Creative Commons BY-NC license
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    Nanomaterials for molecular signal amplification in electrochemical nucleic acid biosensing: recent advances and future prospects for point-of-care diagnostics

    L. Bezinge, A. Suea-Ngam, A. J. deMello and C. Shih, Mol. Syst. Des. Eng., 2020, Advance Article , DOI: 10.1039/C9ME00135B

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