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Functionalized gold nanoparticles: promising and efficient diagnostic and therapeutic tools for HIV/AIDS

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Abstract

Functionalized gold nanoparticles are recognized as promising vehicles in the diagnosis and treatment of human immunodeficiency virus (HIV) owing to their excellent biocompatibility with biomolecules (like DNA or RNA), their potential for multivalency and their unique optical and structural properties. In this context, this review article focuses on the diverse detection abilities and delivery and uptake methodologies of HIV by targeting genes and proteins using gold nanoparticles on the basis of different shapes and sizes in order to promote its effective expression. In addition, recent trends in gold nanoparticle mediated HIV detection, delivery and uptake and treatment are highlighted considering their cytotoxic effects on healthy human cells.

Graphical abstract: Functionalized gold nanoparticles: promising and efficient diagnostic and therapeutic tools for HIV/AIDS

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Article information


Submitted
20 Aug 2020
Accepted
31 Aug 2020
First published
01 Oct 2020

RSC Med. Chem., 2020, Advance Article
Article type
Review Article

Functionalized gold nanoparticles: promising and efficient diagnostic and therapeutic tools for HIV/AIDS

S. Gulati, P. Singh, A. Diwan, A. Mongia and S. Kumar, RSC Med. Chem., 2020, Advance Article , DOI: 10.1039/D0MD00298D

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