Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 5, 2020
Previous Article Next Article

Synthesis and 18F-radiolabeling of thymidine AMBF3 conjugates

Author affiliations

Abstract

In pursuit of 18F-labeled nucleosides for positron emission tomography (PET) imaging, we report on the chemical and radiochemical synthesis of two thymidine (dT) analogs, dT-C5-AMBF3 and dT-N3-AMBF3, that are radiofluorinated by isotope exchange (IEX) and studied as PET imaging agents in mice with tumor xenografts. dT-C5-AMBF3 shows preferential, and tumor-specific, uptake over dT-N3-AMBF3. This work provides a new synthetic method in order to access new nucleoside tracers for PET imaging.

Graphical abstract: Synthesis and 18F-radiolabeling of thymidine AMBF3 conjugates

Back to tab navigation

Supplementary files

Article information


Submitted
17 Feb 2020
Accepted
09 Apr 2020
First published
23 Apr 2020

RSC Med. Chem., 2020,11, 569-576
Article type
Research Article

Synthesis and 18F-radiolabeling of thymidine AMBF3 conjugates

A. A. W. L. Wong, J. Lozada, M. L. Lepage, C. Zhang, H. Merkens, J. Zeisler, K. Lin, F. Bénard and D. M. Perrin, RSC Med. Chem., 2020, 11, 569
DOI: 10.1039/D0MD00054J

Social activity

Search articles by author

Spotlight

Advertisements