Issue 5, 2020

Synthesis and 18F-radiolabeling of thymidine AMBF3 conjugates

Abstract

In pursuit of 18F-labeled nucleosides for positron emission tomography (PET) imaging, we report on the chemical and radiochemical synthesis of two thymidine (dT) analogs, dT-C5-AMBF3 and dT-N3-AMBF3, that are radiofluorinated by isotope exchange (IEX) and studied as PET imaging agents in mice with tumor xenografts. dT-C5-AMBF3 shows preferential, and tumor-specific, uptake over dT-N3-AMBF3. This work provides a new synthetic method in order to access new nucleoside tracers for PET imaging.

Graphical abstract: Synthesis and 18F-radiolabeling of thymidine AMBF3 conjugates

Supplementary files

Article information

Article type
Research Article
Submitted
17 Feb 2020
Accepted
09 Apr 2020
First published
23 Apr 2020

RSC Med. Chem., 2020,11, 569-576

Synthesis and 18F-radiolabeling of thymidine AMBF3 conjugates

A. A. W. L. Wong, J. Lozada, M. L. Lepage, C. Zhang, H. Merkens, J. Zeisler, K. Lin, F. Bénard and D. M. Perrin, RSC Med. Chem., 2020, 11, 569 DOI: 10.1039/D0MD00054J

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