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Online informatics resources to facilitate cancer target and chemical probe discovery

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Abstract

The advances in cancer genomics, chemical biology, high-throughput screening technologies, and synthetic medicinal chemistry have tremendously expanded the biological space of cancer targets and chemical space of bioactive small molecules to interrogate oncogenic signaling. To explore and leverage these exponentially growing cancer-associated data, a great number of computational tools, databases, and algorithms have been developed. This review summarizes recent cancer-related web resources that allow researchers working at the interface of chemical, biological, and cancer genomics fields to integrate clinical and genomics data for specific actionable targets and selective chemical compounds to facilitate cancer therapeutic discovery.

Graphical abstract: Online informatics resources to facilitate cancer target and chemical probe discovery

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Article information


Submitted
09 Jan 2020
Accepted
30 Mar 2020
First published
09 Apr 2020

RSC Med. Chem., 2020, Advance Article
Article type
Review Article

Online informatics resources to facilitate cancer target and chemical probe discovery

X. Yang, H. Fu and A. A. Ivanov, RSC Med. Chem., 2020, Advance Article , DOI: 10.1039/D0MD00012D

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