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An epigrammatic status of the ‘azole’-based antimalarial drugs

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Abstract

The development of multidrug resistance in the malarial parasite has sabotaged majority of the eradication efforts by restraining the inhibition profile of first line as well as second line antimalarial drugs, thus necessitating the development of novel pharmaceutics constructed on appropriate scaffolds with superior potency against the drug-resistant and drug-susceptible Plasmodium parasite. Over the past decades, the infectious malarial parasite has developed resistance against most of the contemporary therapeutics, thus necessitating the rational development of novel approaches principally focused on MDR malaria. This review presents an epigrammatic collation of the epidemiology and the contemporary antimalarial therapeutics based on the ‘azole’ motif.

Graphical abstract: An epigrammatic status of the ‘azole’-based antimalarial drugs

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Article information


Submitted
09 Oct 2019
Accepted
26 Nov 2019
First published
23 Dec 2019

RSC Med. Chem., 2020, Advance Article
Article type
Review Article

An epigrammatic status of the ‘azole’-based antimalarial drugs

M. Sharma and P. Prasher, RSC Med. Chem., 2020, Advance Article , DOI: 10.1039/C9MD00479C

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