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Meridianin D analogues possess antibiofilm activity against Mycobacterium smegmatis

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Abstract

The formation of bacterial biofilms significantly decreases the efficacy of antibiotic treatments. Herein, we've investigated the antibiofilm properties of the natural product meridianin D and a library of analogues against Mycobacterium smegmatis. As a result, we discovered several analogues that both inhibit and disperse M. smegmatis biofilms.

Graphical abstract: Meridianin D analogues possess antibiofilm activity against Mycobacterium smegmatis

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Article information


Submitted
30 Sep 2019
Accepted
29 Oct 2019
First published
16 Dec 2019

RSC Med. Chem., 2020, Advance Article
Article type
Research Article

Meridianin D analogues possess antibiofilm activity against Mycobacterium smegmatis

S. M. Brackett, K. E. Cox, S. L. Barlock, W. M. Huggins, D. F. Ackart, R. J. Bassaraba, R. J. Melander and C. Melander, RSC Med. Chem., 2020, Advance Article , DOI: 10.1039/C9MD00466A

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