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Application of triazoles as bioisosteres and linkers in the development of microtubule targeting agents

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Abstract

The triazole ring system has emerged as an exciting prospect in the optimization studies of promising lead molecules in the quest for new drugs for clinical usage. Several marketed drugs possess these versatile moieties that are used in a wide range of medical indications. This stems from the unique intrinsic properties of triazoles, which impart stability to the basic pharmacophoric unit with an added advantage of being a bioisostere of different chemical functionalities. In the last decade, the use of triazoles as bioisosteres and linkers in the development of microtubule targeting agents has been extensively investigated. The present review highlights the advances in this promising area of drug discovery and development.

Graphical abstract: Application of triazoles as bioisosteres and linkers in the development of microtubule targeting agents

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Article information


Submitted
23 Sep 2019
Accepted
15 Jan 2020
First published
29 Jan 2020

RSC Med. Chem., 2020, Advance Article
Article type
Review Article

Application of triazoles as bioisosteres and linkers in the development of microtubule targeting agents

M. S. Malik, S. A. Ahmed, I. I. Althagafi, M. A. Ansari and A. Kamal, RSC Med. Chem., 2020, Advance Article , DOI: 10.1039/C9MD00458K

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