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Pore structure and particle shape modulates the protein corona of mesoporous silica particles

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Abstract

The protein corona of mesoporous silica particles is significantly affected by their morphology, pore structure and size. High aspect ratio particles with large 12 nm pores have a high proportion of low molecular weight proteins in comparison to spherical particles with 5 nm pores, which show a homogenous protein coating which is generally constant in protein composition after long incubation times in serum. The pre-formation of a protein corona prior to incubation with microglia cells enhances the cellular uptake of spherical particles but not facetted or high aspect ratio particles.

Graphical abstract: Pore structure and particle shape modulates the protein corona of mesoporous silica particles

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Article information


Submitted
10 Apr 2020
Accepted
23 Jun 2020
First published
25 Jun 2020

This article is Open Access

Mater. Adv., 2020, Advance Article
Article type
Communication

Pore structure and particle shape modulates the protein corona of mesoporous silica particles

K. Giri, I. Kuschnerus, M. Lau, J. Ruan and A. Garcia-Bennett, Mater. Adv., 2020, Advance Article , DOI: 10.1039/D0MA00188K

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