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Controlling the block sequence of multi-block oligomer ligands for neutralization of a target peptide

Abstract

A series of block oligomers consisting of the same monomer composition but a different block sequence was prepared via reversible addition-fragmentation chain transfer (RAFT) polymerization to screen high affinity ligands for a toxic peptide. Activity and affinity screening of mono-, di-, and tri-block oligomers revealed that in addition to the localization and combination of functional groups, the sequence of the functional block and end groups are of significant importance to design the ligands that bind and neutralize the peptide.

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Article information


Submitted
31 Mar 2020
Accepted
30 Jun 2020
First published
30 Jun 2020

This article is Open Access

Mater. Adv., 2020, Accepted Manuscript
Article type
Communication

Controlling the block sequence of multi-block oligomer ligands for neutralization of a target peptide

H. Takimoto, S. Katakami, Y. Miura and Y. Hoshino, Mater. Adv., 2020, Accepted Manuscript , DOI: 10.1039/D0MA00149J

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