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Reduction of Taylor–Aris dispersion by lateral mixing for chromatographic applications

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Abstract

Chromatographic columns are suffering from Taylor–Aris dispersion, especially for slowly diffusing molecules such as proteins. Since downscaling the channel size to reduce Taylor–Aris dispersion meets fundamental pressure limitations, new strategies are needed to further improve chromatography beyond its current limits. In this work we demonstrate a method to reduce Taylor–Aris dispersion by lateral mixing in a newly designed silicon AC-electroosmotic flow mixer. We obtained a reduction in κaris by a factor of three in a 40 μm × 20 μm microchannel, corresponding to a plate height gain of 2 to 3 under unretained conditions at low to high Pe values. We also demonstrate an improvement of a reverse-phase chromatographic separation of coumarins.

Graphical abstract: Reduction of Taylor–Aris dispersion by lateral mixing for chromatographic applications

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Article information


Submitted
30 Jul 2020
Accepted
22 Sep 2020
First published
22 Sep 2020

Lab Chip, 2020, Advance Article
Article type
Paper

Reduction of Taylor–Aris dispersion by lateral mixing for chromatographic applications

E. Y. Westerbeek, J. G. Bomer, W. Olthuis, J. C. T. Eijkel and W. De Malsche, Lab Chip, 2020, Advance Article , DOI: 10.1039/D0LC00773K

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