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Self-detachable UV-curable polymers for open-access microfluidic platforms

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Abstract

This study presents an ultraviolet (UV)-curable polymer which is applicable to open-access microfluidic platforms. The UV-curable polymer was prepared by mixing trimethylolpropane triacrylate (TMPTA), 1,6-hexanediol diacrylate (HDDA), polyethylene glycol-diacrylate (PEG-DA), and Irgacure 184. The polymer resin is optically transparent before and after UV-assisted curing and showed good biocompatibility when culturing multiple types of cells on the nanopatterned polymer substrate. The polymer has good adhesion with poly(dimethylsiloxane) (PDMS) even under large deformation and showed a low swelling ratio when exposed to water, suggesting a possibility to be used as a substrate for an organ on a chip. Furthermore, because the polymers have controllable hydrolysis ability depending on the composition, long-term 3D cell culture and subsequent biological analysis with harvested cells are possible. The self-detachable synthesized UV-curable polymer may help the advancement of biomedical studies using in vitro cell culture.

Graphical abstract: Self-detachable UV-curable polymers for open-access microfluidic platforms

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Supplementary files

Article information


Submitted
11 Jun 2020
Accepted
01 Oct 2020
First published
02 Oct 2020

Lab Chip, 2020, Advance Article
Article type
Paper

Self-detachable UV-curable polymers for open-access microfluidic platforms

D. Tahk, S. Bang, S. Hyung, J. Lim, J. Yu, J. Kim, N. L. Jeon and H. N. Kim, Lab Chip, 2020, Advance Article , DOI: 10.1039/D0LC00604A

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