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Issue 18, 2020
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A modular microarray imaging system for highly specific COVID-19 antibody testing

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Abstract

To detect the presence of antibodies in blood against SARS-CoV-2 in a highly sensitive and specific manner, here we describe a robust, inexpensive ($200), 3D-printable portable imaging platform (TinyArray imager) that can be deployed immediately in areas with minimal infrastructure to read coronavirus antigen microarrays (CoVAMs) that contain a panel of antigens from SARS-CoV-2, SARS-1, MERS, and other respiratory viruses. Application includes basic laboratories and makeshift field clinics where a few drops of blood from a finger prick could be rapidly tested in parallel for the presence of antibodies to SARS-CoV-2 with a test turnaround time of only 2–4 h. To evaluate our imaging device, we probed and imaged coronavirus microarrays with COVID-19-positive and negative sera and achieved a performance on par with a commercial microarray reader 100× more expensive than our imaging device. This work will enable large scale serosurveillance, which can play an important role in the months and years to come to implement efficient containment and mitigation measures, as well as help develop therapeutics and vaccines to treat and prevent the spread of COVID-19.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing

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Supplementary files

Article information


Submitted
26 May 2020
Accepted
11 Jul 2020
First published
03 Aug 2020

This article is Open Access

Lab Chip, 2020,20, 3302-3309
Article type
Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

P. N. Hedde, T. J. Abram, A. Jain, R. Nakajima, R. Ramiro de Assis, T. Pearce, A. Jasinskas, M. N. Toosky, S. Khan, P. L. Felgner, E. Gratton and W. Zhao, Lab Chip, 2020, 20, 3302
DOI: 10.1039/D0LC00547A

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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
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    [Original citation] - Published by The Royal Society of Chemistry.

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