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Dynamically directing cell organization via micro-hump structure patterned cell-adhered interfaces

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Abstract

Cell adhesion plays an important role in cell communication, organ formation and tissue maintenance. Spatial microstructure patterning has the capability to regulate cell functions such as cell adhesion and cell proliferation as well as cellular mechanical properties. In this study, we present a simple method to fabricate micro-hump patterned interfaces based on electrohydrodynamic jet (E-jet) printing to control and direct cell organization. Micro-hump structures were rapidly fabricated by E-jet printing and arbitrary cell patterns can be achieved by selective cell adhesion induced by this surface topography. Furthermore, cellular mechanical properties were regulated by changing the density of microstructures. The technique we proposed could dynamically direct cell organization in a controlled manner, providing help for exploring the fundamental mechanism of cell adhesion and sensing.

Graphical abstract: Dynamically directing cell organization via micro-hump structure patterned cell-adhered interfaces

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Supplementary files

Article information


Submitted
10 May 2020
Accepted
03 Jun 2020
First published
04 Jun 2020

Lab Chip, 2020, Advance Article
Article type
Paper

Dynamically directing cell organization via micro-hump structure patterned cell-adhered interfaces

W. Yang, L. Sun, S. Cai, Y. Chen, W. Liang, P. Zhou, H. Yu, Y. Wang and L. Liu, Lab Chip, 2020, Advance Article , DOI: 10.1039/D0LC00477D

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