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Issue 21, 2020
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Integration of paper microfluidic sensors into contact lenses for tear fluid analysis

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Abstract

In this article, using the integration of paper microfluidics within laser-inscribed commercial contact lenses, we demonstrate the multiplexed detection of clinically relevant analytes including hydrogen ions, proteins, glucose, nitrites and L-ascorbic acid, all sampled directly from model tears. In vitro measurements involved the optimization of colorimetric assays, with readouts collected, stored and analyzed using a bespoke Tears Diagnostics smartphone application prototype. We demonstrate the potential of the device to perform discrete measurements either for medical diagnosis or disease screening in the clinic or at the point-of-care (PoC), with future applications including monitoring of ocular infections, uveitis, diabetes, keratopathies and assessing oxidative stress.

Graphical abstract: Integration of paper microfluidic sensors into contact lenses for tear fluid analysis

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Article information


Submitted
11 May 2020
Accepted
28 Aug 2020
First published
04 Sep 2020

Lab Chip, 2020,20, 3970-3979
Article type
Paper

Integration of paper microfluidic sensors into contact lenses for tear fluid analysis

R. Moreddu, M. Elsherif, H. Adams, D. Moschou, M. F. Cordeiro, J. S. Wolffsohn, D. Vigolo, H. Butt, J. M. Cooper and A. K. Yetisen, Lab Chip, 2020, 20, 3970
DOI: 10.1039/D0LC00438C

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