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Issue 7, 2020
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Low-frequency flexural wave based microparticle manipulation

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Manipulation of microparticles and bio-samples is a critical task in many research and clinical settings. Recently, acoustic based methods have garnered significant attention due to their relatively simple designs, and biocompatible and precise manipulation of small objects. Herein, we introduce a flexural wave based acoustofluidic manipulation platform that utilizes low-frequency (4–6 kHz) commercial buzzers to achieve dynamic particle concentration and translation in an open fluid well. The device has two primary modes of functionality, wherein particles can be concentrated in pressure nodes that are present on the bottom surface of the device, or particles can be trapped and manipulated in streaming vortices within the fluid domain; both of these functions result from flexural mode vibrations that travel from the transducers throughout the device. Throughout our research, we numerically and experimentally explored the wave patterns generated within the device, investigated the particle concentration phenomenon, and utilized a phase difference between the two transducers to achieve precision movement of fluid vortices and the entrapped particle clusters. With its simple, low-cost nature and open fluidic chamber design, this platform can be useful in many biological, biochemical, and biomedical applications, such as tumor spheroid generation and culture, as well as the manipulation of embryos.

Graphical abstract: Low-frequency flexural wave based microparticle manipulation

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Supplementary files

Article information

22 Jan 2020
28 Feb 2020
First published
10 Mar 2020

Lab Chip, 2020,20, 1281-1289
Article type

Low-frequency flexural wave based microparticle manipulation

H. Bachman, Y. Gu, J. Rufo, S. Yang, Z. Tian, P. Huang, L. Yu and T. J. Huang, Lab Chip, 2020, 20, 1281
DOI: 10.1039/D0LC00072H

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