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A Microfluidic Approach to Micromembrane Synthesis for Complex Release Profiles of Nanocarriers

Abstract

Physically crosslinked microscale biomembranes synthesized from pure chitosan are designed and demonstrated for pH-triggered release of embedded functionalized mesoporous silica nanoparticles. Nanoparticle-loaded membranes are formed in a microfluidic channel at the junction between accurately controlled co-flowing streams to achieve highly tuneable membrane properties. After formation, the loaded membranes remain stable until contact with physiological acidic conditions, resulting in controlled nanoparticle release. Furthermore, nanoparticle-loaded membranes with complex layered architectures are synthesized using different flow schemes, thus enabling customized nanoparticle release profiles. These novel materials are well-suited for integration within small medical devices as well as off-chip applications.

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Supplementary files

Article information


Submitted
13 Jan 2020
Accepted
13 Feb 2020
First published
14 Feb 2020

Lab Chip, 2020, Accepted Manuscript
Article type
Communication

A Microfluidic Approach to Micromembrane Synthesis for Complex Release Profiles of Nanocarriers

N. Jia, E. Rosella, E. Juère, R. Pouliot, F. Kleitz and J. Greener, Lab Chip, 2020, Accepted Manuscript , DOI: 10.1039/D0LC00039F

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