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An implantable multifunctional neural microprobe for simultaneous multi-analyte sensing and chemical delivery

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Abstract

A multifunctional chemical neural probe fabrication process exploiting PDMS thin-film transfer to incorporate a microfluidic channel onto a silicon-based microelectrode array (MEA) platform, and enzyme microstamping to provide multi-analyte detection is described. The Si/PDMS hybrid chemtrode, modified with a nano-based on-probe IrOx reference electrode, was validated in brain phantoms and in rat brain.

Graphical abstract: An implantable multifunctional neural microprobe for simultaneous multi-analyte sensing and chemical delivery

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Article information


Submitted
07 Jan 2020
Accepted
18 Mar 2020
First published
20 Mar 2020

Lab Chip, 2020, Advance Article
Article type
Communication

An implantable multifunctional neural microprobe for simultaneous multi-analyte sensing and chemical delivery

B. Wang, X. Wen, Y. Cao, S. Huang, H. A. Lam, T. “. Liu, P. Chung, H. G. Monbouquette, P. Chiou and N. T. Maidment, Lab Chip, 2020, Advance Article , DOI: 10.1039/D0LC00021C

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