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Issue 3, 2020
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Ultrafast star-shaped acoustic micromixer for high throughput nanoparticle synthesis

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Abstract

We present an acoustically actuated microfluidic mixer, which can operate at flowrates reaching 8 ml min−1, providing a 50-fold improvement in throughput compared to previously demonstrated acoustofluidic approaches. The device consists of a robust silicon based micro-mechanical oscillator, sandwiched between two polymeric channels which guide the fluids in and out of the system. The chip is actuated by application of an oscillatory electrical signal onto a piezoelectric disk coupled to the substrate by adhesive. At the optimal frequency, this acoustofluidic system can homogenise two fluids with a relative mixing efficiency of 91%, within 4.1 ms from first contact. The micromixer has been used to synthesize two different systems: Budesonide nanodrugs with an average diameter of 80 ± 22 nm, and DNA nanoparticles with an average diameter of 63.3 ± 24.7 nm.

Graphical abstract: Ultrafast star-shaped acoustic micromixer for high throughput nanoparticle synthesis

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Article information


Submitted
26 Nov 2019
Accepted
23 Dec 2019
First published
23 Dec 2019

Lab Chip, 2020,20, 582-591
Article type
Paper

Ultrafast star-shaped acoustic micromixer for high throughput nanoparticle synthesis

N. H. An Le, H. Deng, C. Devendran, N. Akhtar, X. Ma, C. Pouton, H. Chan, A. Neild and T. Alan, Lab Chip, 2020, 20, 582
DOI: 10.1039/C9LC01174A

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