Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



AF4-ICP-MS as a powerful tool for the separation of gold nanorods and nanospheres

Author affiliations

Abstract

An analytical methodology based on asymmetric flow field flow fractionation (AF4) hyphenated to inductively coupled plasma mass spectrometry (ICP-MS) has been developed to separate gold nanorods (AuNRs) and nanospheres (AuNSs). This separation is of special interest because the latter are the main impurity in the synthesis of AuNRs by seeding growth procedures, and quality control tools are highly demanded. AF4-ICP-MS separation was performed using a regenerated cellulose membrane (molecular weight cut-off, MWCO, of 10 kDa), a 350 μm thick spacer and a phosphate buffer (1 mM NaH2PO4, 1 mM Na2HPO4 at pH 7) with 0.01% SDS as carrier. Several experimental parameters, such as focusing conditions and elution cross flow, and the injection/focusing time were optimized. Working under the optimum separation conditions, an adequate resolution was achieved between the void peak, commercially available AuNSs and AuNRs. The optimized method was successfully applied to the analysis of the products obtained in the synthesis procedure for AuNRs of 4.6 aspect ratio. Absorption molecular spectroscopy and transmission electron microscopy (TEM) have been used as complementary techniques.

Graphical abstract: AF4-ICP-MS as a powerful tool for the separation of gold nanorods and nanospheres

Back to tab navigation

Supplementary files

Article information


Submitted
27 Mar 2020
Accepted
11 May 2020
First published
11 May 2020

J. Anal. At. Spectrom., 2020, Advance Article
Article type
Technical Note

AF4-ICP-MS as a powerful tool for the separation of gold nanorods and nanospheres

S. López-Sanz, N. R. Fariñas, M. Zougagh, R. D. C. R. Martín-Doimeadios and Á. Ríos, J. Anal. At. Spectrom., 2020, Advance Article , DOI: 10.1039/D0JA00123F

Social activity

Search articles by author

Spotlight

Advertisements