Jump to main content
Jump to site search

Issue 20, 2020
Previous Article Next Article

Stannous chloride as a low toxicity and extremely cheap catalyst for regio-/site-selective acylation with unusually broad substrate scope

Author affiliations

Abstract

This work reports stannous chloride (SnCl2)-catalyzed regio-/site-selective acylation with unusually broad substrate scope. In addition to 1,2- and 1,3-diols and glycosides containing cis-vicinal diol, the substrate scope also includes glycosides without cis-vicinal diol. For such a substrate scope, usually, only methods using stoichiometric amounts of organotin reagents can lead to the same protection pattern with high selectivities and highly isolated yields (84–97% in most cases). Therefore, SnCl2, as a low toxicity and extremely cheap reagent, should be the best catalyst for regio-/site-selective acylation compared with any previously reported reagents.

Graphical abstract: Stannous chloride as a low toxicity and extremely cheap catalyst for regio-/site-selective acylation with unusually broad substrate scope

Back to tab navigation

Supplementary files

Article information


Submitted
10 Aug 2020
Accepted
07 Sep 2020
First published
08 Sep 2020

Green Chem., 2020,22, 6936-6942
Article type
Paper

Stannous chloride as a low toxicity and extremely cheap catalyst for regio-/site-selective acylation with unusually broad substrate scope

J. Lv, J. Yu, G. Feng, T. Luo and H. Dong, Green Chem., 2020, 22, 6936
DOI: 10.1039/D0GC02739A

Social activity

Search articles by author

Spotlight

Advertisements