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Issue 20, 2020
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Light-driven deracemization of phosphinothricin by engineered fatty acid photodecarboxylase on a gram scale

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Abstract

A fatty acid photodecarboxylase (CvFAP) based photobiocatalytic deracemization of phosphinothricin (PPT) was developed. The engineered CvFAP enabled the kinetic resolution of racemic PPT on a gram scale, providing unreacted L-PPT with high yields and excellent stereoselectivity. In contrast to previous biocatalytic approaches, this efficient light-driven process required neither NADPH recycling nor a PPT precursor.

Graphical abstract: Light-driven deracemization of phosphinothricin by engineered fatty acid photodecarboxylase on a gram scale

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Article information


Submitted
05 Aug 2020
Accepted
24 Sep 2020
First published
29 Sep 2020

Green Chem., 2020,22, 6815-6818
Article type
Communication

Light-driven deracemization of phosphinothricin by engineered fatty acid photodecarboxylase on a gram scale

F. Cheng, H. Li, D. Wu, J. Li, Y. Fan, Y. Xue and Y. Zheng, Green Chem., 2020, 22, 6815
DOI: 10.1039/D0GC02696D

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