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Issue 20, 2020
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Construction of benzothiophene fused pyrrolidone in water via a catalyst-free process and a mechanism study

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Abstract

A novel three-component domino reaction towards benzothiophene fused pyrrolidone derivatives was developed in an environmentally benign manner. The reaction proceeded well in aqueous media, and delivered the desired products in high yields with excellent selectivity. Density functional calculations located a multi-step reaction pathway and identified the intramolecular nucleophilic addition step to be the rate-determining step.

Graphical abstract: Construction of benzothiophene fused pyrrolidone in water via a catalyst-free process and a mechanism study

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Article information


Submitted
01 Jun 2020
Accepted
31 Aug 2020
First published
11 Sep 2020

Green Chem., 2020,22, 6798-6803
Article type
Communication

Construction of benzothiophene fused pyrrolidone in water via a catalyst-free process and a mechanism study

J. Shen, A. Yu, L. Zhang and X. Meng, Green Chem., 2020, 22, 6798
DOI: 10.1039/D0GC01860K

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