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Zn(0)-Catalysed mild and selective hydrogenation of nitroarenes

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Abstract

The hydrogenation of nitroarenes is one of the most important strategies for the preparation of anilines. However, it is still a great challenge to develop mild and efficient synthetic routes toward aniline synthesis, particularly those employing both non-precious metal catalysts and low-pressure H2. Herein, we report a highly efficient protocol for the selective hydrogenation of nitroarenes in neutral H2O using H2 (1 atm) over a heterogeneous Zn(0) catalyst under mild conditions. The nitro groups of an array of nitroarenes can be converted into –NH2 with up to 99% conversions and a selectivity of >99%, even when functionalized with easily reducible substituents, or in the presence of aromatic ketones or styrene. This study might open an avenue for the selective hydrogenation of nitroarenes over a zinc catalyst using 1 atm H2.

Graphical abstract: Zn(0)-Catalysed mild and selective hydrogenation of nitroarenes

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Article information


Submitted
05 Apr 2020
Accepted
24 Jun 2020
First published
24 Jun 2020

Green Chem., 2020, Advance Article
Article type
Paper

Zn(0)-Catalysed mild and selective hydrogenation of nitroarenes

S. Sun, M. Du, R. Zhao, X. Jv, P. Hu, Q. Zhang and B. Wang, Green Chem., 2020, Advance Article , DOI: 10.1039/D0GC01202E

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