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Photochemical synthesis of acetals utilizing Schreiner's thiourea as the catalyst

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Abstract

Acetalization of aldehydes is an area of great importance in Organic Chemistry for both synthetic and biological puproses. Herein, we report a mild, inexpensive and green photochemical protocol, where Schreiner's thiourea (N,N′-bis[3,5-bis(trifluoromethyl)-phenyl]-thiourea) is utilized as the catalyst and cheap household lamps as the light source. A variety of aromatic and aliphatic aldehydes were converted into acetals in good to high yields (23 examples, 36–96% yield) and an example of the synthesis of a cyclic acetal is provided. The reaction mechanism was also studied.

Graphical abstract: Photochemical synthesis of acetals utilizing Schreiner's thiourea as the catalyst

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Supplementary files

Article information


Submitted
30 Mar 2020
Accepted
06 May 2020
First published
06 May 2020

This article is Open Access

Green Chem., 2020, Advance Article
Article type
Paper

Photochemical synthesis of acetals utilizing Schreiner's thiourea as the catalyst

N. Spiliopoulou, N. F. Nikitas and C. G. Kokotos, Green Chem., 2020, Advance Article , DOI: 10.1039/D0GC01135E

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