Issue 12, 2020

Production of formate from CO2 gas under ambient conditions: towards flow-through enzyme reactors

Abstract

A flow-through bi-enzymatic reactor was developed to produce formate from carbon dioxide gas (CO2). The reaction operates under ambient conditions without hydrogen gas (H2) and involves a high performance formate dehydrogenase from Methylobacterium extorquens AM1 (MeFoDH1). The tandem reaction features in situ regeneration of the nicotinamide adenine dinucleotide (1,4-NADH) cofactor performed by a highly active mutant of the phosphite dehydrogenase from Pseudomonas stutzeri, without any side reaction. One of the highest turnover numbers reported to date in the literature was reached (6700) giving a high space–time yield of 0.6 mmolformate min−1 L−1reactor.

Graphical abstract: Production of formate from CO2 gas under ambient conditions: towards flow-through enzyme reactors

Supplementary files

Article information

Article type
Communication
Submitted
17 Mar 2020
Accepted
15 May 2020
First published
15 May 2020

Green Chem., 2020,22, 3727-3733

Production of formate from CO2 gas under ambient conditions: towards flow-through enzyme reactors

M. Baccour, A. Lamotte, K. Sakai, E. Dubreucq, A. Mehdi, K. Kano, A. Galarneau, J. Drone and N. Brun, Green Chem., 2020, 22, 3727 DOI: 10.1039/D0GC00952K

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