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HCl·DMPU-assisted one-pot and metal-free conversion of aldehydes to nitriles

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Abstract

We report an efficient HCl·DMPU assisted one-pot conversion of aldehydes into nitriles. The use of HCl·DMPU as both an acidic source as well as a non-nucleophilic base constitutes an environmentally mild alternative for the preparation of nitriles. Our protocol proceeds smoothly without the use of toxic reagents and metal catalysts. Diverse functionalized aromatic, aliphatic and allylic aldehydes incorporating various functional groups were successfully converted to nitriles in excellent to quantitative yields. This protocol is characterized by a broad substrate scope, mild reaction conditions, and high scalability.

Graphical abstract: HCl·DMPU-assisted one-pot and metal-free conversion of aldehydes to nitriles

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Supplementary files

Article information


Submitted
02 Mar 2020
Accepted
12 May 2020
First published
14 May 2020

Green Chem., 2020, Advance Article
Article type
Paper

HCl·DMPU-assisted one-pot and metal-free conversion of aldehydes to nitriles

S. R. Mudshinge, C. S. Potnis, B. Xu and G. B. Hammond, Green Chem., 2020, Advance Article , DOI: 10.1039/D0GC00757A

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