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Issue 10, 2020
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Ethyl lactate-involved three-component dehydrogenative reactions: biomass feedstock in diversity-oriented quinoline synthesis

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Abstract

Three-component reactions of ethyl/methyl lactate, anilines and aldehydes providing quinolines have been developed via simple iron(III) chloride catalysis without using an additional organic medium or external oxidant. This three-component protocol shows high efficiency and broad substrate tolerance, allowing quick access to diverse quinoline products under neat reaction conditions. The results reported herein disclose important new applications of green biomass feedstock in the clean synthesis of valuable organic products.

Graphical abstract: Ethyl lactate-involved three-component dehydrogenative reactions: biomass feedstock in diversity-oriented quinoline synthesis

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Supplementary files

Article information


Submitted
01 Mar 2020
Accepted
30 Apr 2020
First published
30 Apr 2020

Green Chem., 2020,22, 3074-3078
Article type
Communication

Ethyl lactate-involved three-component dehydrogenative reactions: biomass feedstock in diversity-oriented quinoline synthesis

L. Yang and J. Wan, Green Chem., 2020, 22, 3074
DOI: 10.1039/D0GC00738B

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