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Base Mediated Benzannulation of α-Cyano Crotonates with Ynones: Facile Synthesis of Benzonitriles and Fluorenes

Abstract

We demonstrate here in a strategic rapid approach for benzonitriles and cyanofluorenes via [3 + 3] benzannulation of readily available alkynones and α-cyanocrotonates, a protocol par excellence for aryl nitriles. This decarboxylative annulation is assisted solely by a base without the need of any catalyst. The only by-product is EtOH (and CO2) and the product is cleanly filtered off the contents after reaction at ambient temperature.

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Article information


Submitted
19 Feb 2020
Accepted
20 Mar 2020
First published
23 Mar 2020

Green Chem., 2020, Accepted Manuscript
Article type
Communication

Base Mediated Benzannulation of α-Cyano Crotonates with Ynones: Facile Synthesis of Benzonitriles and Fluorenes

M. K. R. Singam, A. Nagi Reddy and S. R. Maddi, Green Chem., 2020, Accepted Manuscript , DOI: 10.1039/D0GC00608D

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