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Issue 8, 2020
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Iridium-catalyzed orthogonal and regioselective synthesis of triazole disulfides in aqueous media under mild conditions

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Abstract

An orthogonal and regioselective synthesis of triazole disulfides in aqueous media under mild conditions has been developed. This simple and practical approach is environment-friendly and compatible with oxygen/water and various complex biological media. It features excellent regioselectivities and chemoselectivities, high yields, good biocompatibility and bioorthogonality. Its applications in the synthesis of carbohydrates and trigger-responsive nanoparticles are further highlights of this aqueous transformation.

Graphical abstract: Iridium-catalyzed orthogonal and regioselective synthesis of triazole disulfides in aqueous media under mild conditions

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Supplementary files

Article information


Submitted
14 Feb 2020
Accepted
24 Mar 2020
First published
25 Mar 2020

Green Chem., 2020,22, 2394-2398
Article type
Communication

Iridium-catalyzed orthogonal and regioselective synthesis of triazole disulfides in aqueous media under mild conditions

M. Li, N. Zheng, J. Li, Y. Zheng and W. Song, Green Chem., 2020, 22, 2394
DOI: 10.1039/D0GC00555J

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