Issue 7, 2020

Concise synthesis of α-amino cyclic boronates via multicomponent coupling of salicylaldehydes, amines, and B2(OH)4

Abstract

We report here a concise synthesis of α-amino cyclic boronates via multicomponent coupling of readily available salicylaldehydes, amines, and B2(OH)4. The process can be carried out at room temperature in ethanol, does not require catalysts or additives, and is easy to scale up. Aminals and ligated boroxines are intermediates in this reaction.

Graphical abstract: Concise synthesis of α-amino cyclic boronates via multicomponent coupling of salicylaldehydes, amines, and B2(OH)4

Supplementary files

Article information

Article type
Communication
Submitted
28 Jan 2020
Accepted
05 Mar 2020
First published
05 Mar 2020

Green Chem., 2020,22, 2184-2190

Concise synthesis of α-amino cyclic boronates via multicomponent coupling of salicylaldehydes, amines, and B2(OH)4

W. Ming, X. Liu, A. Friedrich, J. Krebs, Y. P. Budiman, M. Huang and T. B. Marder, Green Chem., 2020, 22, 2184 DOI: 10.1039/D0GC00346H

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